Outlook 2010 stuck in safe mode - just uninstall KB3114409
Yesterday (December 9th, 2015) Microsoft rolled out a faulty update for Microsoft Office 2010 (KB3114409) which accidentally causes Outlook 2010 to start in safe mode systematically , ignoring registry and computer settings. To solve the problem, simply go to the "Programs and features" control panel applet, click on "View installed updates", search for KB3114409, and uninstall it . After you reboot your computer, Outlook will start normally again. This solution has been tested successfully at work for dozens of users. Microsoft stated: “ After you install this update, Outlook 2010 may start only in safe mode. If this issue occurs, uninstall the update. This update is no longer available now. " Source: Microsoft message boards